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基于碳稳定同位素分析的科尔奇辛的来源歧视

Hanyang Zheng¹, Jun Zhu^1,2, Zhuotong Cai¹

¹School of Investigation, People's Public Security University of China, Beijing, China.

Journal of forensic sciences

|July 17, 2025

概括

法医科学家现在可以通过其碳稳定同位素签名来追踪一种有毒类化合物 - - 科尔奇辛的起源. 这种新方法通过提供可靠的来源歧视,提高了中毒事件的识别.

科学领域:

法医化学法医化学
分析化学分析化学

背景情况:

科尔奇辛是一种有毒的类化合物,经常用于刑事中毒案件.
在法医科学中,追踪有毒物质来源至关重要,而菌根原产地歧视尤其重要.
科尔奇辛的稳定同位素特征是来源比较的关键,但其复杂的结构和高分子量挑战了精确的分析.

研究的目的:

建立一种分析科尔奇辛碳稳定同位素的方法.
为了提高法医调查中菌素的可追溯性.
为了克服与复杂分子的精确稳定同位素分析相关的挑战.

主要方法:

使用气体染色学-燃烧-同位素比质谱法 (GC-C-IRMS).
实验条件被系统地优化,以解决不完整的氧化问题.
方法验证评估了储存条件和矩阵效应的影响.

主要成果:

精确的碳稳定同位素测量得到了低于0.3‰的标准偏差.
储存条件和矩阵效应对同位素比率的确定没有显著影响.
该方法有效地根据δ¹³C值区分了来自三个不同的来源的菌素样本.

结论:

成功建立了一种可靠和强大的协议,用于对科尔奇辛稳定碳同位素分析.
这种方法显著提高了在法医科学中菌素的可追溯性潜力.
开发的技术有助于化学指纹识别中毒事件.

关键词:

在 GC-C-IRMS 中.分析条件优化优化分析条件优化科尔奇辛 (Colchicine) 是一种可怕的药物.歧视是一种歧视.稳定的碳同位素是稳定的碳同位素可以追溯的可追溯性.

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