经过过导管大动脉置换后,中风频率和严重性的性别差异
Vijay A Joshi1, Emily M Bucholz1,2, Marshall Roll1,3,4
1University of Colorado School of Medicine Aurora CO USA.
Journal of the American Heart Association
|July 17, 2025
概括
妇女经历过过导管大动脉置换 (TAVR) 后,残疾性中风的发生率更高. 这项研究强调了需要针对性别的策略,以减少女性TAVR患者中风风险.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 干预心脏病学 干预心脏病学
背景情况:
- 脑卒中是通过导管的大动脉置换 (TAVR) 后的一个已知的并发症.
- 目前关于TAVR后中风和中风严重程度的性别差异的数据有限.
- 致残性中风显著影响患者的生活质量和结果.
研究的目的:
- 为了研究TAVR后中风发生率和严重程度的性别差异.
- 确定接受TAVR的男性和女性中风风险的潜在差异.
主要方法:
- 使用国家住院患者样本 (2016-2021) 进行回顾性队列研究.
- 通过经过验证的基于索赔的算法确定中风和中风严重程度.
- 将致残性中风定义为导致死亡或非家庭出院的中风.
- 多变量逻辑回归分析调整共变量和脑栓塞保护使用.
主要成果:
- 与男性相比,女性的整体住院中风发病率较高 (2.31%对1.69%).
- 女性中风率的增加主要是由于残疾性中风的发病率较高 (1.61%对1.01%).
- 在非致残性中风的发病率上没有观察到任何显著的性别差异.
结论:
- 与男性相比,在当代实践中接受TAVR的女性面临的整体和残疾性中风风险更高.
- 这些发现强调了开发定制策略的必要性,以减轻女性TAVR患者中风风险.
- 解决性别特定的脆弱性对于改善TAVR后的结果至关重要.
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