孕期孕产妇糖尿病是子女视和折射失误的危险因素 - 一项大型全国性研究
Nir Amitai1,2, Tomer Kerman1,2, Tamar Eshkoli3,4
1Faculty of Health Sciences, Joyce & Irving Goldman Medical School, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
概括
怀孕期间产妇糖尿病增加了子女对视和折射误差 (RE) 的风险. 母亲的HbA1c水平较高与儿童患上这些眼部疾病的风险更高有关.
科学领域:
- 眼科医生 眼科 眼科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 公共卫生
背景情况:
- 怀孕期间产妇糖尿病是一个越来越令人担忧的问题.
- 母亲血糖控制与后代眼部发育之间的潜在联系需要进行调查.
研究的目的:
- 为了确定孕产妇怀孕期间的糖尿病是否与子女视和折射误差 (RE) 的风险增加有关.
- 探索不同类型的孕产妇糖尿病和血糖控制 (HbA1c水平) 对这些风险的影响.
主要方法:
- 使用克拉利特卫生服务 (以色列,2001-2023) 的电子病历进行回顾性队列研究.
- 根据母亲糖尿病状况 (第1型,第2型,妊娠期或没有糖尿病) 来分类出生.
- 使用混合模型和通用估计方程进行统计分析,以比较眼部状况并计算调整后的赔率比率.
主要成果:
- 分析了超过50万名母亲的子女记录.
- 糖尿病母亲的后代表现出明显更高的斜视 (调整的OR 1.40) 和折射误差 (调整的OR 1.61) 的患病率.
- 增加的母体HbA1c水平 (>6.5%) 与子女的斜视 (调整的OR 1.78) 和折射误差 (调整的OR 1.97) 的风险大幅增加有关.
结论:
- 怀孕期间的孕产妇糖尿病是导致子女眼和折射失误的重要危险因素.
- 较低的血糖控制,即高HbA1c水平,进一步放大了这种风险.
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