认知障碍与心力衰竭的演变的关联
Quan Huynh1,2, Kawa Haji1, Carmine G DePasquale3
1Baker Heart and Diabetes Research Institute Melbourne Australia.
Journal of the American Heart Association
|July 17, 2025
概括
认知障碍,即使在临床前心力衰竭 (HF) 中,也会显著增加患临床HF的风险. 这种风险被左心室功能障碍等条件放大,突出显示了认知健康在HF进展中的重要性.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 心力衰竭 (HF) 越来越多地与认知障碍有关,但确切的关系及其对HF发展的影响尚不清楚.
- 现有研究尚未完全阐明认知功能如何与HF风险因素和亚临床HF进展相互作用.
研究的目的:
- 研究认知功能与已确定的HF风险因素之间的关联.
- 确定认知障碍如何影响患有亚临床HF的个体发生临床HF的发展.
主要方法:
- 在澳大利亚招募了814名临床前 (无症状) 和1152名临床 (症状) HF参与者.
- 使用蒙特利尔认知评估 (MOCA <26) 评估认知功能和通过全球纵向应变 (<16%) 评估左心室功能障碍.
- 随访临床前HF参与者平均45个月,以追踪发生的临床HF或死亡率.
主要成果:
- 基线认知障碍 (MOCA <26) 与年龄,HF阶段,糖尿病,心房动,慢性肺病,脑血管疾病和心脏功能障碍 (全球纵向应变,左心房体积指数,左心室填充压力) 独立相关.
- 认知障碍显著放大了年龄,并发症指数和全球纵向菌株与临床HF的关联.
- 患有临床前HF和认知障碍或左心室功能障碍的参与者患临床HF的风险增加了一倍;患有这两种障碍的人面临4倍的风险增加.
结论:
- 认知障碍是发生性临床心力衰竭的重要独立预测因素.
- 这些发现强调了认知健康在心力衰竭进展中的关键作用,无论心脏功能或其他传统风险因素如何.
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