在感染后嗅觉功能障碍中以烯为中心的嗅觉训练:双路线方法
Aytug Altundag1, Emirhan Harbi1, Melih Cayonu2
1Department of Otorhinolaryngology, Biruni University School of Medicine, İstanbul, Türkiye.
The Laryngoscope
|July 17, 2025
概括
与传统方法相比,一种新的双路径嗅觉训练方法,结合了后鼻刺激和基于的气味剂,在感染后嗅觉功能障碍 (PIOD) 的患者中显著改善了结果.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 嗅觉功能障碍研究 嗅觉功能障碍研究
背景情况:
- 传染后嗅觉功能障碍 (PIOD) 在嗅觉康复中提出了重大挑战.
- 传统的嗅觉训练 (COT) 协议在解决嗅觉通路的复杂性方面存在局限性.
- 特定气味剂 (如烯) 的神经治疗潜力需要在PIOD管理方面进一步研究.
研究的目的:
- 为了比较经典的嗅觉训练 (COT) 与PIOD的新型双路线方法 (TCOT) 的疗效.
- 在嗅觉训练中研究整合后鼻刺激和基于的气味剂的影响.
- 评估烯丰富的气味剂对PIOD患者嗅觉和认知功能的神经治疗作用.
主要方法:
- 一百一十七名患有PIOD的患者被随机分配到COT或修改后的双路线协议 (TCOT).
- 该TCOT协议整合了使用基气味剂的正鼻和鼻后嗅觉刺激.
- 在12个月内评估了嗅觉功能 (嗅探棒TDI,气味识别),质严重程度和认知投诉 (CFQ-5).
主要成果:
- 以烯为中心的正鼻和鼻后嗅觉训练 (TCOT) 组在9个月和12个月后在TDI和气味识别得分上表现出显著更大的改善 (p < 0.001).
- 鼻后嗅觉评分和临床意义上的TDI增长 (≥6分) 在TCOT组显著更高.
- 与对照组相比,TCOT参与者表现出最显著的减轻帕罗斯米亚严重程度和认知投诉 (CFQ-5分数).
结论:
- 整合鼻后嗅觉训练和富含烯的气味剂可以提高PIOD的嗅觉康复结果.
- TCOT方法提供了一个有前途的多式联络策略,用于管理感染后嗅觉功能障碍.
- 应考虑在PIOD康复中临床应用以烯为中心的双路径嗅觉训练.
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