与性别染色体异常相关的心理健康诊断
Adaiah Soibi-Harry1, Oumaima Kaabi1, Doris Fadoju2
1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
概括
性染色体形症 (SCA) 患者的精神健康诊断率更高,包括饮食障碍,行为障碍和自杀念头. 这突显了SCA患者医疗保健中的一个被忽视的领域.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 性染色体形 (SCA) 包含具有非典型的X/Y染色体数量的情况.
- SCA与各种心理健康诊断 (MHD) 有关.
- 了解SCA中MHD的患病率对于患者护理至关重要.
研究的目的:
- 调查Klinefelter综合征 (KS) 和特纳综合征 (TS) /特纳马赛克主义 (TM) 个体中精神健康诊断的流行情况.
- 将SCA患者队列中的MHD患病率与非SCA对照组进行比较.
- 为了确定特定的MHD类别,增加了SCA的流行率.
主要方法:
- 电子健康记录进行了选,以确定KS,TS或TM患者.
- 检查了型数据和临床笔记,以确认患者.
- 使用波桑回归计算流行率 (PR) 和95%置信区间 (CI) 的匹配病例控制设计.
主要成果:
- 凯斯病患者患有更高的食/饮食障碍 (PR=4.2),破坏性/冲动控制/行为障碍 (PR=3.4) 和自杀念头 (PR=3.5) 的患病率.
- TS/TM患者表现出神经发育障碍 (PR=3.6) 和破坏性/冲动控制/行为障碍 (PR=2.0) 的更高患病率.
- 患病率因年龄而异,但信心区间在很大程度上重叠.
结论:
- 患有SCA的个人经历的精神健康并发症的负担显著增加.
- 在SCA患者中,心理健康的管理是医疗保健的优先事项,但未得到充分解决.
- 对SCA群体的心理健康需要进一步的研究和临床关注.
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