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Updated: Sep 15, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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作为PPARγ固的共同绑定接口,SIRT1 N-终端域是PPARγ的共同绑定接口

Caique Camargo Malospirito1,2, Gabriel Ernesto Jara1, Víctor Ulian Antunes1

  • 1Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.

Proteins
|July 17, 2025
PubMed
概括

研究人员模拟了Sirtuin 1 (SIRT1) 如何与氧酶增殖器激活受体马 (PPARγ) 结合,以改善胰岛素敏感性. SIRT1 N端域是定PPARγ的关键,为胰岛素抵抗提供了新的药物标.

关键词:
在 PPARγγ 中.一个SIRT1系统.胰岛素耐药性是一种胰岛素耐药性.分子建模分子建模蛋白质生物化学 蛋白质生物化学蛋白质生物物理学的生物物理学

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