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的生物标志物 深度大脑刺激

Gloria Ortiz-Guerrero1, Nicholas M Gregg

  • 1Department of Neurology, Mayo Clinic, Rochester, Minnesota, U.S.A.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
|July 17, 2025
PubMed
概括

针对耐药性的深度大脑刺激 (DBS) 的目标是thalamic网络. 传感和生物标志物的进步为改善控制提供了个性化的治疗策略.

科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 生物医学工程 生物医学工程

背景情况:

  • 深度大脑刺激 (DBS) 是FDA批准的药物耐药焦点.
  • 设备技术的进步和体立体电脑电图增强了对网络的理解.

研究的目的:

  • 审查的电生理学,成像和临床生物标志物 DBS.
  • 专注于发作检测,目标参与,网络刺激性和风险预测的生物标志物.

主要方法:

  • 在thalamic立体电脑电图 (sEEG) 的背景下对生物标志物的检查.
  • 对网络映射和调制的被动记录和主动刺激协议的审查.
  • 对启用传感器的DBS系统进行评估.

主要成果:

  • thalamic sEEG提供了对中皮质大脑皮质大脑网络的洞察.
  • 生物标志物显示出对发作检测,参与追踪和风险预测的潜力.
  • 具有传感功能的DBS系统为个性化治疗提供了新的功能.

结论:

  • 生物标志物发现和不断发展的设备功能对于的个性化DBS至关重要.
关键词:
适应性刺激是一种适应性刺激.慢性大脑记录 慢性大脑记录神经调节是一种神经调节.单脉冲电刺激是一种单脉冲电刺激.泰拉姆体内脑电图 (thalamic sEEG) 是一种

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  • 需要进行翻译的努力来实现个性化DBS的新范式.
  • 未来的方向包括将先进的生物标志物纳入临床实践,以量身定制管理.