相关实验视频
Updated: Sep 15, 2025
10:45
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
14.5K
脂肪性肝病:酒精消费有什么作用?
Gianni Testino1,2,3, Carmen Fucile4, Maurizia Gnocchi4
1Unit of Addiction and Hepatology, Alcohological Regional Center, ASL3 Liguria, Polyclinic San Martino Hospital, Genoa, Italy - gianni.testino@asl3.liguria.it.
Minerva medica
|July 17, 2025
概括
早期检测脂肪性肝病 (SLD) 和肝纤维化非常重要. 降低饮酒门和促进生活方式的改变可以降低心血管和癌症的风险.
科学领域:
- 肝病学和胃肠道学
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与酒精有关的肝病 (ALD) 具有共同的风险因素,并增加心血管和瘤风险.
- 酒精消费 (AC) 和代谢因素之间的协同作用需要重新评估诊断值.
- 肝纤维化是长期生存和肝/肝外病理学的关键预测因素.
研究的目的:
- 审查目前关于脂肪性肝病 (SLD) 亚型的文献和指导方针,重点关注早期检测和风险分层.
- 探索酒精消费 (AC) 和代谢因素对SLD进展和相关并发症的影响.
- 强调早期肝纤维化 (LF) 检测和改变生活方式的重要性,以改善患者的治疗结果.
主要方法:
- 在2024年12月31日之前发表的科学文献的叙事综述.
- 对最近关于脂肪性肝病 (SLD) 的指导方针的分析.
- 包括来自PubMed,科学网络,Scopus和谷歌学者的数据.
主要成果:
- 由于协同作用,建议将MASLD和MetALD区分的切断值降低到女性每天10g,男性每天20g.
- 强调了即使在轻微的AC中也会增加患病和死亡的风险,特别是在年轻人中,主张完全戒酒.
- 在90%以上的SLD患者中确认了心脏代谢风险因素,强调了需要心脏病学家和肝病学家合作的必要性.
- 建议用超声波和弹性图进行初步评估,对所有出现肝功能变化,代谢综合征,T2DM或心血管疾病的新患者进行初步评估.
- 建议基于风险的监测计划 (高风险半年,中低风险一年) 对于肝硬化和非肝硬化患者.
结论:
- 早期识别AC,包括低剂量消费和LF,对于减轻肝脏和肝脏外疾病至关重要.
- 由早期检测驱动的生活方式修改,既可以作为SLD的首要预防,也可以作为治疗.
- 心脏病专家和肝脏病专家之间的合作努力对于管理SLD患者心脏代谢风险因素的高患病率至关重要.
- 提高人们对SLD作为肝脏和非肝脏疾病的重要风险因素的认识,对于公共卫生倡议至关重要.
相关概念视频
01:30Liver Physiology
1.3K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
1.3K
01:26Diseases of the Liver and Gallbladder
1.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.0K
01:24Overview of Lipid Metabolism
2.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.5K
01:24Chronic Pancreatitis I: Introduction
166
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
166
01:24Liver Regeneration
3.4K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.4K
01:27Liver Histology
1.6K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
1.6K