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Updated: Sep 15, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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机械学的焦点:一个庞大的宏循环促进了功能组的反应性 [2]

Thomas Pickl1, Claire Stark1, Diego Briganti1,2

  • 1Catalysis Research Center (CRC) & TUM School of Natural Sciences, Department of Chemistry, Technical University of Munich, Ernst-Otto-Fischer Str. 1, 85747 Garching, Germany.

Journal of the American Chemical Society
|July 17, 2025
PubMed
概括

在机械互锁的分子中,大型宏循环通常会降低反应性. 然而,这项研究揭示了 [2]rotaxane,其中宏循环加速了Fmoc的剥离,证明纠可以增强化学反应性.

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