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在第一次中度重度或重度急性胰腺炎后,胰腺外分泌功能不全的发展
Outi Lindström1, Elina Lietzen2, Panu Mentula1
1Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Scandinavian journal of gastroenterology
|July 17, 2025
概括
大约三分之一的严重急性胰腺炎 (AP) 患者患有胰腺外分泌功能不全 (PEI). 持续的PEI是通过便中低水平的弹性酶-1在出院后一年确定的.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 内分泌学 在内分泌学.
- 手术研究的研究.
背景情况:
- 胰腺亡是严重急性胰腺炎 (AP) 的并发症,可能导致胰腺外分泌功能不全 (PEI).
- 了解第一个AP攻击后PEI的发病率和预测因素对于患者管理至关重要.
研究的目的:
- 为了前性地研究从中度重度或重度AP的第一个发作中恢复的患者PEI的发展.
- 为了确定预测持续PEI的因素,免费后一年.
主要方法:
- 招募了70名患有AP的患者,PEI通过便弹性酶-1 (FE-1) 评估在住院期间和出院后的1-2个月和12个月.
- 持续PEI被定义为FE-1<200μg/g在12个月.
- 分析了PEI的预测因素.
主要成果:
- 在完成这项研究的52名患者中,67%的FE-1在12个月内正常,而6%的PEI中度和27%的严重.
- 最初FE-1正常的4名患者 (17%) 患上了持续性PEI.
- 新发型糖尿病,广泛的胰腺亡 (>50%),胰腺体亡,以及初始低FE-1水平预测持续PEI.
结论:
- 大约三分之一的患者经历了中度严重或严重的AP的第一次发作后会发展为PEI.
- 胰腺功能倾向于在一年内恢复,但持续的PEI甚至可以发生在最初正常水平的人身上.
- 在住院期间发现的预测因素可以帮助识别有风险的患者,以便更密切地监测和干预.
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