轴性脊椎关节炎疾病参数的最小季节性变化:基于登记的研究
Emma Onkamo1, Björn Sundström2,3, Bengt Wahlin4
1Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, 901 87, Sweden. emma.onkamo@umu.se.
Rheumatology international
|July 17, 2025
概括
轴性脊椎关节炎 (axSpA) 的疾病活动显示较小的季节性变化,参数在春季略有下降. 然而,这些变化通常太小,对axSpA.患者来说临床意义不大.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 轴性脊椎关节炎 (axSpA) 是一种慢性炎症状况,其特征是疾病活动波动.
- 关于季节对axSpA疾病活动,福祉和功能状态的潜在影响的研究有限.
研究的目的:
- 调查轴性脊柱关节炎 (axSpA) 疾病活动度的季节性变化.
- 评估季节和患者报告的结果之间的关系,包括福祉和功能能力.
主要方法:
- 利用瑞典风湿病学质量登记的大量数据集 (来自5,197个人的44,987项评估).
- 采用循环立方线的通用添加模型来分析疾病参数的年度变化.
主要成果:
- 客观和患者报告的axSpA测量均表现出一致的年度变化,春季的疾病活动趋势较低.
- 平均CRP水平因月份而异,在7月达到峰值,并在3月达到最低.
- 在BASDAI,BASFI和BASMI得分中观察到显著的季节性变化,特别是在疾病持续时间超过10年的患者中.
结论:
- 确定了axSpA疾病参数的统计学上显著的季节性变化.
- 观察到的疾病活动的绝对变化是最小的,并且可能在临床上与患者管理无关.
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