维生素D补充剂对人类肠道微生物群的影响:随机对照试验的系统审查
Falak Zeb1, Tareq Osaili1,2,3, Mona Hashim1,2
1Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Nutrition reviews
|July 17, 2025
概括
维生素D补充剂对肠道微生物群产生积极影响,增加了Bifidobacterium和Lactobacillus等有益细菌. 需要进一步的研究来标准化方法并探索长期的健康影响.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
背景情况:
- 维生素D对整体健康至关重要.
- 新出现的证据表明,维生素D与肠道微生物群组成之间存在联系.
- 肠道微生物群影响各种生理过程.
研究的目的:
- 系统地审查对维生素D补充对人类肠道微生物群的影响的随机对照试验 (RCT).
- 分析微生物组成和多样性的变化.
主要方法:
- 从2015年到2024年,对主要数据库 (MEDLINE,科学网,Scopus,Cochrane图书馆) 进行全面的文献搜索.
- 包括14个RCT与1458名参与者,专注于高通量测序数据.
- 遵循PRISMA系统审查指南.
主要成果:
- 维生素D补充剂调节了肠道微生物群,增加了有益的细菌 (Bifidobacterium, Lactobacillus) 和 Bacteroidetes/Firmicutes 的比例.
- 在一些研究中观察到增强的微生物多样性 (α和β多样性).
- 在生物标志物如calprotectin和trimethylamine N-oxide中发现了变化.
结论:
- 维生素D补充剂在调节肠道微生物群方面表现有前途.
- 研究设计中的异质性需要用于因果关系评估的标准化方法.
- 研究结果支持针对微生物组的个性化营养策略.
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