在美国成年癌症患者中,COVID-19疫苗增强剂的摄入量和有效性
Jacek Skarbinski1,2,3,4, Eric P Elkin1, Yonah C Ziemba5
1Division of Research, Kaiser Permanente Northern California, Pleasanton.
JAMA oncology
|July 17, 2025
概括
COVID-19疫苗增强剂显著保护癌症患者免受严重疾病和住院治疗. 需要采取干预措施,以增加这种脆弱人群的增强剂吸收.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 患有癌症的个人面临更高的严重COVID-19结果的风险.
- 在这个人群中,额外的COVID-19疫苗剂量 (增剂) 的特定益处仍在调查中.
研究的目的:
- 评估COVID-19疫苗增强剂在预防癌症患者中严重的COVID-19结果方面的有效性.
- 确定需要接种疫苗 (NNV) 的数量,以防止这个队列中的一个住院.
主要方法:
- 在四个美国医疗保健系统中进行了一项回顾性队列研究.
- 数据包括接受化疗或免疫治疗的癌症患者,分析了与单价和双价COVID-19疫苗增剂相关的结果.
主要成果:
- 单价增强剂显示,针对COVID-19住院治疗的疫苗有效率为29.2%,NNV为166. 对于被诊断为COVID-19和ICU入院者也观察到显著的VE.
- 双对应助推剂显示了29.9%的VE对住院治疗和30.1%的VE对ICU入院治疗,NNV为451以防止住院治疗.
结论:
- 在患有癌症的患者中,COVID-19增强疫苗可以显著保护他们免受严重的COVID-19.
- 疫苗接种量较低需要采取干预措施,以提高这一高风险群体的疫苗接种率.
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