在使用KDIGO和适应年龄的eGFR值的欧洲成年人中减少eGFR的患病率
Megan E Astley1,2, Nicholas C Chesnaye1,3, Giovanni Gambaro4
1Amsterdam UMC location University of Amsterdam, ERA Registry, Medical Informatics, Amsterdam, The Netherlands.
概括
慢性病 (CKD) 的适应年龄的定义显著改变了欧洲成年人功能减弱的患病率估计. 需要进一步的研究来将这些新的门与临床结果联系起来.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 目前的慢性病 (CKD) 定义不包括与年龄相关的功能下降.
- 已经提出了适应年龄的CKD定义,但它们对患病率估计的影响尚不清楚.
研究的目的:
- 用标准KDIGO值与三种适应年龄的eGFR值来比较欧洲成年人中降低估计球过率 (eGFR) 的流行率.
主要方法:
- 在9项基于人口的研究中,对超过250万欧洲成年人的数据进行了横截面分析.
- 使用欧洲功能联盟 (EKFC) 方程计算的eGFR.
- 使用KDIGO评估的降低EGFR的患病率,分类适应年龄和两个连续的适应年龄和性别的门.
主要成果:
- 在40岁以下的成年人中,KDIGO的患病率最低 (<1%),而根据年龄的适应值在3%至7%之间.
- 在65岁以上的成年人中,根据年龄调整的门导致患病率较低 (10-19%) 与KDIGO (45%) 相比.
- 适应年龄的门显著改变了流行率估计,特别是在老年人中.
结论:
- 实施适应年龄的eGFR值可能会改变功能减弱的估计患病率.
- 在CKD定义改变之前,这些新型适应年龄值的临床相关性和与结果的关联需要进一步调查.
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