癌症患者的COVID-19相关住院和死亡的危险因素:国家癌症研究所COVID-19在癌症患者研究 (NCCAPS) 中
Brian I Rini1, Ana F Best2, Mel D Bowman3
1Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
JAMA oncology
|July 17, 2025
概括
接受化疗的癌症患者因COVID-19而面临更高的住院风险. 接种疫苗显著降低了住院风险,突出了疫情期间对癌症患者的重要性.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 癌症患者和治疗方法与较差的COVID-19结果有关.
- 识别特定的风险因素对于在这个脆弱人群中管理COVID-19至关重要.
研究的目的:
- 确定癌症患者中与COVID-19严重程度 (住院治疗或死亡) 相关的患者,治疗和癌症类型因素.
- 分析COVID-19对癌症治疗连续性的影响.
主要方法:
- 潜在的纵向队列研究 (国家癌症研究所的癌症患者研究中的COVID-19 - NCCAPS).
- 在SARS-CoV-2检测阳性后14天内包括成人癌症患者.
- 多变量回归模型用于评估30天和90天内住院和死亡的风险因素.
主要成果:
- 接受化疗和中风,心房动或肺栓塞病史增加了住院的风险.
- 之前针对SARS-CoV-2的疫苗接种与住院的风险降低有关.
- COVID-19导致了癌症治疗的重大中断,特别是在前30天内.
结论:
- COVID-19显著影响癌症患者,导致住院治疗,治疗中断和死亡率.
- 癌症患者严重COVID-19的危险因素包括化疗和先前存在的心血管/脑血管疾病.
- 在这个群体中,接种疫苗是预防COVID-19住院的关键保护因素.
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