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Updated: Sep 15, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

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碳素酸生物异构剂 提高Nurr1主因子的选择性

Tanja Stiller1, Christian Gege2, Wael Saeb3

  • 1Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

Journal of medicinal chemistry
|July 17, 2025
PubMed
概括

研究人员开发了一种新型的Nurr1激动剂,来自vidofludimus,可以选择性地准Nurr1而不抑制DHODH. 这种新化合物通过促进神经元健康,显示出治疗神经退行性疾病的潜力.

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