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Ravi K Dinesh1, Chengkun Wang1,2, Yuanhao Qu1,3

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America.

PLoS pathogens
|July 17, 2025
PubMed
概括

这项研究确定了新的宿主因子,豆类素 (LGMN) 和KCNA6,它们有助于SARS-CoV-2进入细胞. 抑制这些因素可能会减少病毒感染,为COVID-19提供潜在的治疗点.

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Coronavirus01:29

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...