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氨基酸涂层使微运动器在生理条件下运行

Jia Sun¹, Yusen Ding², Yicheng Ye¹

¹National Medical Products Administration Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Proceedings of the National Academy of Sciences of the United States of America

|July 17, 2025

概括

研究人员使用氨基酸表面修饰改进了二氧化 (TiO2) 微电机的离子耐受性. 这一突破在生理环境中增强了微/纳米动力 (MNM) 推进,使新的生物医学应用成为可能.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

高离子强度的生理环境通过抑制电双层来阻碍微/纳米电机 (MNM) 推进.
这种限制特别影响依赖电解质扩散和电泳的电机.
克服离子诱导火对于生物环境中MNM应用至关重要.

研究的目的:

开发一种通用和有效的战略,以提高光驱二氧化 (TiO2) 微电机的离子耐受性.
通过氨基酸表面修饰来研究改善离子耐受性的机制.
探索这些改造微电机在生物医学应用中的潜力,特别是瘤亡诱导.

主要方法:

使用氨基酸L-氨酸 (Arg) 的二氧化 (TiO2) 微电机的表面修改.
通过测量高离子强度溶液中的微电机推进,评估离子耐受性.
修改和裸体TiO2微电机的表面特性,包括表面导电性.
光驱动推进与超声波的组合用于声敏化和反应性氧物种 (ROS) 生成.

主要成果:

与裸体TiO2微电机相比,用L-氨酸处理的TiO2微电机表现出超过200倍的离子耐受性.
增强的离子耐受性归因于氨基酸修饰电机的表面导电性增加.
表面修改策略证明对其他自电泳驱动电机有效.
经过修改的TiO2微电机,作为声敏化剂,在与超声波相结合时有效诱导in situ瘤亡.

结论:

氨基酸表面修饰,特别是用L-氨酸,提供了一种简单但有效的策略来提高TiO2微电机的离子耐受性.
这种方法克服了在生理环境中运行的MNM的重大局限性.
增强的离子耐受性和光/超声组合能力为MNM在生物医学研究和治疗应用 (包括癌症治疗) 中开辟了新的途径.

关键词:

电光泳是一种电光泳.离子耐受性离子耐受性轻量驱动的微型发动机声动力学疗法是一种声动力学疗法.表面的修改表面的修改

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相关概念视频

Mechanical Protein Function

Mechanical Protein Function

Mechanical Protein Functions

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.