视觉神经炎后的跨突触退化导致的初级视觉皮层损伤:神经成像研究的系统审查
Maria N Hsiao1, Juliana S Krupinsk2, Nayara L Froio3
1Department of Neurology, Division of Neurosurgery, University of Sao Paulo Medical School, Sao Paulo, Brazil; Comprehensive Brain Research Network, Brazil.
概括
超突触性退化 (TSD) 在视神经炎后导致视觉通路损伤. 神经成像显示多发性硬化症和神经炎光学谱系障碍患者的初级视觉皮层缩和光学辐射损伤.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是指放射学
背景情况:
- 超突触性退化 (TSD) 是神经通路损伤的一个拟议机制.
- 视神经炎对视觉通路和初级视觉皮层 (V1) 的影响尚不清楚.
- 了解视神经炎的TSD对于管理视力缺陷至关重要.
研究的目的:
- 系统地审查和评估视觉神经炎后TSD导致的初级视觉皮层 (V1) 损伤.
- 综合神经成像证据的结构和微观结构的变化在视觉路径.
主要方法:
- 在PROSPERO注册的系统文献审查 (no. 42023479709) 提供给我们的.
- 在EMBASE,PubMed和Scopus数据库中进行了搜索 (2023年7月25日).
- 包括10项使用ROBINS-I.评估的观察性研究 (9个MS,1个NMOSD).
主要成果:
- 神经成像 (DTI,结构MRI) 显示V1体积和厚度减少.
- 观察到光学辐射完整性的显著损害.
- 与对照组相比,患者的分数异构性 (FA) 降低,平均扩散性 (MD) 增加.
结论:
- 在MS和NMOSD等脱髓化疾病中,TSD显著影响视觉通路后视觉神经炎.
- 视神经损伤导致V1变性,由白质完整性丧失和皮质缩证明.
- 需要进一步的研究来标准化成像和调查各种视神经炎病因.
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