追溯采访显示,在可逆半球抑制后,没有意识到弱点:使用选择性麻醉进行功能评估的探索性研究
Hiroaki Hosokawa1, Kazuo Kakinuma2, Shin-Ichiro Osawa3
1Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Japan Society for the Promotion of Science, Chiyoda, Tokyo, Japan; Department of Psychology, Keio University, Minato, Tokyo, Japan.
概括
在脑损伤后对肢体疲弱的不意识在两个半球中同样普遍,挑战了对右半球优势的传统观点. 这项研究使用了功能评估选择性麻醉 (SAFE) 来暂时抑制大脑区域并评估意识缺陷.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 神经学 神经学
背景情况:
- 没有意识到四肢疲软 (半球疏忽) 通常与右半球损伤有关.
- 然而,这种缺陷的横向性在神经学研究中仍在争论中.
研究的目的:
- 通过可逆大脑抑制模型,研究半球不意识到弱点的横向化.
- 重新评估右半球优势的既定概念,以治疗运动缺陷的无意识症.
主要方法:
- 追溯分析了53名患者的86次选择性麻醉功能评估 (SAFE) 会议.
- 通过将麻醉剂注入动脉分支中,SAFE 暂时抑制了皮质功能.
- 患者在实时和康复后被评估是否意识到 contralateral 肢体软弱 (paresis).
主要成果:
- 在78.8%的左半球和76.5%的右半球抑制中,没有意识到弱点.
- 在M2上层部门的抑制显示,与M2下层部门相比,没有意识的比例更高.
- 实时和康复后的意识评估显示出高一致性 (93%).
结论:
- 不意识到弱点的频率是半球平衡,质疑假定的右半球主导地位.
- 对于研究暂时的意识缺陷而不会造成永久的结构损伤,SAFE是一个有价值的工具.
- 这些发现可能有助于将药理学和基于病变的方法整合到大脑行为映射中.
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