与登革热相关的诊断延迟的发生率,持续时间和危险因素:基于人口的研究
Aaron C Miller1, Alan T Arakkal2, Joseph E Cavanaugh2
1Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
The American journal of tropical medicine and hygiene
|July 17, 2025
概括
在旅行者中诊断登革热是具有挑战性的,因为症状重叠. 这项研究发现,近四分之一的登革热患者错过了诊断机会,延迟了治疗.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 登革热是国际旅行者发烧性疾病的重要原因.
- 登革热的症状模仿其他感染,往往会推迟及时诊断.
- 及时诊断对于有效的患者管理和预防严重后果至关重要.
研究的目的:
- 分析美国登革热病例的诊断延迟和错失机会.
- 确定导致患者登革热诊断延迟的因素.
- 估计错过诊断机会的频率和持续时间.
主要方法:
- 使用Merative MarketScan研究数据库 (2001-2021) 进行的回顾性队列研究.
- 确定了5992例登革热病例,比较了诊断前症状呈现频率.
- 使用引导分析来估计诊断延迟的持续时间和风险因素.
主要成果:
- 超过一半 (51.6%) 的登革热患者在诊断前进行了具有特征性症状的检查.
- 估计有22.8%的患者至少错过了一次诊断机会.
- 平均诊断延迟为4.02天;延迟在周末和抗生素/阿片类药物处方中更为常见.
结论:
- 登革热的诊断延迟是常见的,有很大的潜力错过机会.
- 周末访问和某些处方可能会增加被延迟登革热诊断的风险.
- 进一步的研究应该集中在改善诊断及时性和识别风险人群.
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