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在外围固体瘤中进行CAR-T细胞治疗和重建性瘤手术-A叙述性综述

Leonard Knoedler¹, Konstantin Herfeld², Daniel A Schaefer³

¹Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, USA; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Berlin, Germany; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Cell reports. Medicine

|July 17, 2025

概括

化学抗原受体 (CAR) -T细胞疗法在与固体瘤的瘤外科手术相结合时显示出有前途. 这种方法可以改善瘤控制,优化手术结果,减少复发.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
手术瘤学手术瘤学

背景情况:

化学抗原受体 (CAR) -T细胞疗法在血液恶性瘤中有效,但在固体瘤中面临挑战.
固体瘤存在诸如异质性,免疫抑制和T细胞透不良等障碍,限制了CAR-T的疗效.
周围固体瘤包括黑色素瘤,肉瘤,乳腺癌和头癌.

研究的目的:

审查CAR-T细胞治疗与外围固体瘤重建性瘤手术的整合.
探索新兴的策略,以加强在固体瘤中CAR-T细胞治疗.
评估CAR-T联合治疗和手术对患者结局的潜在影响.

主要方法:

关于固体瘤中CAR-T细胞疗法的当前文学和临床研究的综述.
讨论先进的CAR-T细胞策略:局部传递,改进的CAR设计和新的抗原标 (HER2,MUC1,GD2,B7-H3).
对将CAR-T疗法与外科手术相结合的协同效应的分析.

主要成果:

新兴的策略在克服CAR-T细胞治疗的固体瘤障碍方面显示出希望.
临床研究表明,结合方法改善了局部瘤控制和优化了手术切除.
将CAR-T治疗与手术相结合可能会降低瘤复发率.

结论:

卡特-T细胞疗法是固体瘤瘤外科手术中的潜在辅助治疗方法.
将CAR-T疗法与手术结合起来,可以积极影响重建性结果.
跨学科的合作对于改善患者在固体瘤管理中的结果至关重要.

关键词:

在CAR-T细胞中.乳腺癌乳腺癌乳腺癌仿制性抗原受体的仿制性抗原受体临床试验是指临床试验中的临床试验.头部和部癌症头部和部癌症免疫疗法免疫疗法恶性黑色素瘤是一种恶性黑色素瘤.重建性手术是重建性的手术.肉瘤肉瘤是一种肉瘤.皮肤癌是皮肤癌.

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