ангиотензин-(1-7) 在糖尿病中调节肠骨髓轴
Kishore Chittimalli1, Ishan Manandhar2, Stephen Adkins3
1Department of Pharmaceutical Sciences, College of Health and Human Sciences, North Dakota State University, Fargo, ND 58105, USA.
Biochemical pharmacology
|July 17, 2025
概括
ангиотензин-(1-7) 可以改善结肠屏障的完整性,并减少糖尿病小鼠的炎症. 这种可以恢复肠道微生物群和骨髓炎症,为治疗糖尿病并发症提供潜力.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 糖尿病与结肠上皮屏障完整性受损和炎症增加有关.
- 骨髓中的骨髓形成在糖尿病中失调,导致系统性炎症.
- ангиотензин-(1-7) (Ang-(1-7) 是一种具有已知的心血管保护作用在糖尿病中的.
研究的目的:
- 调查Ang-(1-7) 是否可以恢复结肠上皮屏障的完整性,并使糖尿病小鼠的骨髓形成正常化.
- 为了确定Ang-(1-7) 是否能改善糖尿病引起的肠道失调和骨髓炎症情形.
主要方法:
- 类型 1 和 db/db 类型 2 型糖尿病小鼠模型被治疗 Ang-(1-7).
- 通过FITC-dextran测定来评估肠道透性.
- 分析了结肠上皮质屏障标记物,肠道干细胞 (ISC),肠道微生物群组成和骨髓炎症概况.
主要成果:
- 在两种糖尿病模型中,Ang-(1-7) 显著逆转了肠道透率的增加.
- 该恢复了结肠中的Wnt3a和β-catenin水平,并减少了骨髓中的促炎单细胞和巨细胞.
- Ang-(1-7) 调节肠道微生物群组成,增加有益细菌,降低三甲基胺N氧化物 (TMAO) 和脂多糖结合蛋白 (LBP) 的血水平.
结论:
- ангиотензин-(1-7) 在改善糖尿病中结肠屏障完整性和炎症的破坏方面表现出显著的潜力.
- 该通过恢复再生性肠干细胞和逆转异常骨髓形成来实现这些效果.
- Ang-(1-7) 为治疗糖尿病胃肠道并发症和全身炎症提供了一个有前途的治疗策略.
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