一种基于水凝的药物输送系统可以减少炎症和氧化应激,以缓解椎间盘退化
Siya Wang1, Yu Zhai2, Minghan Liu3
1College of Bioengineering, Chongqing University, Chongqing 400044, China.
Acta biomaterialia
|July 17, 2025
概括
一种新的水凝药物递送系统 (HPPC) 通过按需释放赛莱科克西布来有效治疗椎间盘退化 (IDD). 这个系统减少了炎症和氧化应激,恢复了IDD模型中的磁盘功能.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 药物输送系统 药物输送系统
背景情况:
- 椎间盘退化 (IDD) 是腰部疼痛的主要原因,由氧化应激和炎症驱动.
- 塞莱科克西布有效治疗IDD,但由于椎间盘血液供应有限,其生物可用性较差.
- 目前用于IDD的治疗方法在退化的磁盘环境中面临药物输送和疗效方面的挑战.
研究的目的:
- 开发一种基于水凝的药物递送系统 (HPPC),用于在退化的脊椎间盘 (IVD) 中有针对性和按需释放赛莱科西布.
- 调查HPPC在减轻与IDD相关的氧化应激和炎症方面的治疗疗效.
- 评估HPPC在恢复椎间盘功能方面的潜力.
主要方法:
- 通过用基二化物和3 - 氨基二酸修改氨酸,并将化物功能化的聚乙烯甘醇和装载着 Celecoxib 的聚多巴胺纳米粒子结合起来,制造 HPPC 水凝.
- 利用动态的希夫基和乙烯链接形成水凝,使其能够对活性氧物种 (ROS) 和低pH反应.
- 在细胞核细胞 (NPC) 和IDD大鼠模型中进行体外和体内研究,以评估炎症,氧化应激和磁盘功能恢复.
主要成果:
- HPPC水凝对退化的IVD微环境表现出反应性,促进按需和持续释放赛莱可西布.
- 惠普克表现出有利的机械性能,可降解性,可注射性和生物相容性.
- 试验室和体内结果显示,HPPC通过调节COX2-PGE2-NFκB和TNFα-P38-MAPK通路,有效地减少了NPC的炎症和氧化应激,并恢复了IDD大鼠的磁盘功能.
结论:
- 开发的动态水凝药物递送系统 (HPPC) 提供了一种有前途的策略,通过实现向的赛莱科克西布递送来增强IDD治疗.
- 由于HPPC能够响应IVD微环境并调节关键炎症通路 (NF-κB和MAPK),因此可以有效地减少炎症和氧化应激.
- 这种方法为改善椎间盘退化治疗和恢复脊柱功能提供了潜在的临床解决方案.
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