在移植接受者中,COVID-19后心血管疾病的风险
Mary G Bowring1, Kasama Manothummetha2, Veraprapas Kittipibul3
1Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
概括
接受脏移植的人在COVID-19后面临高心血管疾病风险. 住院治疗COVID-19显著提高了这种风险,类似于之前的心血管事件.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 移植接受者 (KTRs) 对心血管疾病 (CVD) 具有独特的风险概况.
- 在KTR中描述COVID-19后心血管疾病风险对于有效的管理策略至关重要.
研究的目的:
- 确定KTRs中COVID-19后心血管疾病的发病率和确定风险因素.
- 评估COVID-19住院治疗对该人口中心血管疾病风险的影响.
主要方法:
- 778名KTR患者的回顾性分析,其中809例是COVID-19症状事件 (2020年3月至2024年1月).
- 综合心血管疾病结局 (急性冠状动脉综合征,中风,心力衰竭,心血管疾病相关死亡) 或COVID-19后1年后的随访.
- 使用最小绝对收缩和选择操作员 (LASSO) 基础的分发危险回归来识别风险因素.
主要成果:
- 在KTRs中,COVID-19后心血管疾病的一年发病率为8.7%.
- 在KTR患者中观察到更高的发病率,他们之前有心血管病史 (19.1%对5.0%).
- 风险因素包括年龄较大,黑人种族,西班牙裔种族,以前的心血管疾病和COVID-19住院治疗;肥胖和remdesivir治疗具有保护作用.
结论:
- 在KTRs中,COVID-19后心血管疾病的风险是相当大的.
- 住院治疗COVID-19的风险相当于之前的心血管事件.
- 针对性CVD风险管理对于KTRs在COVID-19感染后至关重要.
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