空气和光污染对大脑和行为功能的影响:潜在的协同作用
Pallavi Sharma1, Brittany D Elliott2, Randy J Nelson1
1Department of Neuroscience, Rockefeller Neuroscience Institute, USA.
Neuroscience and biobehavioral reviews
|July 17, 2025
概括
夜间的人工光 (ALAN) 和空气污染对大脑健康有害. 它们的综合作用,包括氧化应激和炎症,需要进一步研究有效的缓解策略.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 全球夜间人工光 (ALAN) 和空气污染日益普遍,这引发了人们的健康问题.
- 无论是ALAN还是空气污染,都独立地与诸如认知衰退和神经退行性疾病等不良大脑健康结果有关.
- 空气污染物可以到达大脑,导致神经病理,而ALAN会扰乱昼夜节律和睡眠.
研究的目的:
- 审查空气和光污染对大脑健康的影响.
- 探索联合暴露的潜在协同效应和潜在机制.
- 确定研究缺口,并呼吁未来对生物途径进行调查.
主要方法:
- 流行病学,临床前和临床研究的文献综述.
- 探索潜在的机制,包括氧化应激,炎症和昼夜干扰.
- 分析ALAN与空气污染对生理和行为结果的相互作用.
主要成果:
- 艾伦和空气污染独立地导致认知衰退,神经退行和行为障碍.
- 潜在的综合效应包括氧化应激,炎症,昼夜节律扰乱,血脑屏障问题和遗传改变.
- 存在复杂的相互作用,需要进一步研究协同效应.
结论:
- 了解ALAN和空气污染对大脑健康的综合影响至关重要.
- 需要进一步的研究来阐明生物途径和协同效应.
- 有效的医疗保健策略需要了解这些环境污染物相互作用.
相关概念视频
Human Genetics
732
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
732
Types of Toxins
2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K
Brain Imaging
318
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
318
Photoreceptors and Visual Pathways
6.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K
Insufficient Sleep and Sleep Deprivation
222
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
222
Attention-Deficit/Hyperactivity Disorder
295
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
295


