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Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
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严重的孕产妇发病率和孕产妇死亡率与怀孕相关,在女性中发生固体器官移植
Yasser Sabr1, Sarka Lisonkova2, Chantal Mayer3
1Department of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, BC; Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
概括
接受了固体器官移植 (SOT) 的妇女面临严重孕产妇发病率和分娩期间长时间住院的风险显著增加. 这凸显了SOT接受者在怀孕期间急需专业护理的迫切需要.
科学领域:
- 产科和妇科 产科和妇科
- 移植手术 移植手术
- 公共卫生 公共卫生
背景情况:
- 固体器官移植 (SOT) 越来越普遍,但对接受者的怀孕结果的数据仍然有限.
- 了解SOT接受者的严重孕产妇发病率 (SMM) 和死亡率对于改善护理至关重要.
研究的目的:
- 为了确定在加拿大的分娩妇女中SOT的流行率.
- 量化SOT接受者与非接受者之间的SMM和产妇死亡率.
主要方法:
- 从2003年到2018年,对加拿大 (不包括北克) 的医院分娩进行了回顾性队列研究.
- 使用标准化条件列表定义的SMM.
- 后勤回归用于计算SOT和不利结果的调整几率比率 (AOR).
主要成果:
- 在超过410万次分娩中,342次涉及SOT接受者 (63%是脏,25%是肝脏).
- 在SOT接收者中,复合SMM率显著更高 (134.5比9.97每1000次交付;AOR 10.8).
- 观察到严重的妊娠前,妊娠后,急性功能衰竭,肝功能衰竭,心脏病和长时间住院的风险增加 (22.3%对1.78%).
结论:
- 对SOT妇女的分娩与严重孕产妇发病率显著增加有关.
- 在这个人群中,长时间住院是常见的,这强调了实质性的临床风险.
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