针对疾病相关营养不良的个性化营养治疗的生物标志物:叙述性综述
Carla Wunderle1, Kai Urbach1, Lena Buchmueller1
1Medical University Department, Division of General Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland.
与疾病相关的营养不良显著增加了患者的发病率和死亡率. 生物标志物可以帮助个性化营养治疗,改善治疗结果并降低住院成人的医疗费用.
科学领域:
- 临床营养学 临床营养学
- 生物标志物在医学中的作用
- 医院住院患者护理 医院住院患者护理
背景情况:
- 与疾病相关的营养不良在住院成年人中很普遍,导致发病率,死亡率和医疗保健成本增加.
- 需要有效的诊断和治疗策略来打击营养不良在医院环境中的不良影响.
研究的目的:
- 审查目前关于使用生物标志物的证据,以在住院成人医疗患者中个性化营养治疗.
- 探索生物标志物的潜力,以表征患者的预后和治疗反应.
主要方法:
- 对最近高质量的随机对照试验和现有文献进行叙述性审查.
- 确定和总结有前途的营养生物标志物,包括炎症,慢性疾病和肌肉健康指标.
- 讨论机器学习和人工智能在生物标志物数据解释中的作用.
主要成果:
- 营养疗法在减少选定患者群体的发病率和并发症方面显示出显著的益处.
- 营养生物标志物和风险查得分有助于患者表型化,以预后和治疗反应.
- 已识别的生物标志物包括C反应性蛋白,互白素-6,肌素,前白蛋白,白蛋白,红细胞分布宽度以及肌肉健康的测量.
结论:
- 生物标志物对于区分病因和指导营养不良的个性化营养治疗干预至关重要.
- 将生物标志物纳入评估工具是优化个性化营养护理的关键.
- 未来的研究应该专注于有效地将生物标志物纳入临床实践,以改善患者的治疗结果.
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