实物检查宣传和prep参与 (scope) 研究:在美国马里兰州巴尔的摩进行非随机临床试验的协议
Kristin E Schneider1, Danielle Friedman Nestadt2, Emily M Martin2
1Department of Health, Behavior and Society, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA kschne18@jhu.edu.
BMJ open
|July 17, 2025
概括
该SCOPE研究测试了一种结合HIV暴露前预防 (PrEP) 和药物检查 (PWUD) 的移动干预措施. 这种方法旨在改善PrEP参与度,并减少高风险人群中过量服用.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 药物使用研究研究 药物使用研究
背景情况:
- 吸毒者 (PWUD) 由于注射药物使用和不断发展的毒品市场,面临高艾滋病毒和过量服用风险.
- 暴露前预防 (PrEP) 和药物检查服务是利用不足的干预措施,以减轻这些危害.
- 街头宣传,移动服务和同行导航可以提高参与度,并减少照顾PWUD的障碍.
研究的目的:
- 评估"检查它"干预措施的影响,这是一个基于社区的移动计划,提供PrEP和药物检查服务.
- 评估干预措施在改善参与艾滋病毒暴露前预防治疗连续护理方面的有效性.
- 确定干预措施对减少参与者中非致命性过量剂量数量的影响.
主要方法:
- 检查物质推广和准备参与 (SCOPE) 研究是一项非随机临床试验.
- 将通过马里兰州巴尔的摩市的街头宣传活动招募500名艾滋病毒风险高的PWUD.
- 参与者将被跟踪18个月,使用随机效应和边缘结构模型分析数据.
主要成果:
- 主要结局包括参与者参与PrEP连续护理和非致命过量剂量的发生率.
- 统计模型将估计干预对这些结果的影响随着时间的推移.
- 研究结果将通过同行评审的出版物和演讲传播.
结论:
- 通过移动推广提供的"Check It"干预措施有可能改善PrEP的吸收率并减少过量服用事件.
- 将药物检查与PrEP服务相结合,可能为PWUD提供一个全面的降低危害的策略.
- 需要进一步的研究来证实这种综合干预措施的长期影响和可扩展性.
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