急性疾病儿童的亚拉托克辛暴露和死亡率:来自CHAIN网络队列的结果
Lei Xia1, Hang Wu2, Ali Faisal Saleem3
1School of Food Science & Nutrition, University of Leeds Faculty of Engineering and Physical Sciences, Leeds, West Yorkshire, UK.
BMJ global health
|July 17, 2025
概括
非洲毒素暴露与未消耗,急性疾病儿童的死亡率有关. 营养不良带来更大的风险,但控制偏素暴露对于公共卫生干预至关重要.
科学领域:
- 环境健康 环境健康
- 儿科健康 儿科健康
- 毒理学 毒理学 毒理学
背景情况:
- 慢性阿弗拉托克辛暴露与肝癌,儿童生长障碍和免疫功能障碍有关.
- 儿童急性疾病和营养 (CHAIN) 网络队列研究了非洲和南亚急性疾病儿童死亡的风险因素.
- 这项研究调查了 aflatoxin暴露在住院患者和出院后死亡率中的作用.
研究的目的:
- 评估阿弗拉托克辛暴露与急性疾病儿童死亡率之间的关联.
- 评估与营养状况和死亡率结果相关的 aflatoxin-albumin adduct (AF-alb) 水平.
主要方法:
- 在CHAIN队列中进行了一个嵌套的案例-队列研究.
- 从住院儿童 (n=755) 和社区参与者 (n=222) 的血清样本使用ELISA分析了AF-alb.
- 儿童按营养状况分层 (不消耗,中度消耗,严重消耗).
主要成果:
- 56%的住院儿童在入院时检测出AF-alb的阳性.
- 与幸存者和社区参与者相比,已故儿童的AF-alb水平较高.
- 亚拉托克辛暴露与未失去孩子的死亡率有显著的相关性 (OR=4.84,p=0.014).
结论:
- 中度到严重的营养不良是死亡的一个更重要的危险因素比急性疾病儿童的亚拉托克辛.
- 非洲毒素暴露可能会导致死亡,特别是在非浪费儿童中.
- 建议在高暴露地区将偏素暴露控制纳入公共卫生干预措施.
关键词:
全球健康 全球健康
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