在动脉中波速的几何依赖:幻象和有限元素研究以及对血管"剪切波"弹性学的影响

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...

In fluid mechanics, shear stresses arise from viscosity, which represents a fluid's internal resistance to deformation. For low-viscosity fluids, like water, these stresses are minimal, simplifying flow analysis by allowing the fluid to be treated as inviscid, or frictionless. In an inviscid fluid, shear stresses are absent, leaving only normal stresses, which act perpendicularly to fluid elements. Notably, pressure — defined as the negative of the normal stress — remains uniform across...

In steady, incompressible flow through a long, straight pipe with a uniform cross-section, the flow in the central region (far from the pipe walls) is irrotational. This irrotational nature means that fluid particles do not rotate around their axes, and a scalar function called the velocity potential, represented by ϕ, can be used to describe their movement. In irrotational flows, the velocity field V is defined as the gradient of the velocity potential:

For incompressible Newtonian fluids, where density remains constant, stresses show a linear relationship with the deformation rate, defined by normal and shear stresses. Normal stresses depend on the pressure exerted on the fluid and the rate of deformation in specific directions, which determines how fluid flows under varying pressures. Shear stresses, on the other hand, act tangentially across fluid layers. They explain how adjacent fluid layers slide relative to one another, connecting...

Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...