在无症状的患有与代谢功能障碍相关的肥胖性肝病的患者中对 Carotid 动脉样硬化症的风险评估
Hana Park1, Ji Young Lee1, Sungwon Park2
1Division of Gastroenterology, Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和MetALD增加了亚临床性动脉动脉样硬化风险,特别是肝脏脂肪和纤维化. 代谢负担和肝病的严重程度是关键因素.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 心血管疾病是代谢功能障碍相关的脂肪性肝病 (MASLD) 患者死亡的主要原因.
- 亚临床性动脉动脉样硬化 (SCA) 是心血管风险的早期指标.
研究的目的:
- 评估SCA和MASLD或MASLD与无症状个体增加酒精摄入量 (MetALD) 之间的关联.
主要方法:
- 一项对韩国56889名无症状成年人进行的横截面研究.
- 通过超声波诊断的肝肥胖症;通过动脉斑块或增加内心介质厚度的SCA.
- 使用FIB-4指数和弹性图进行评估的肝纤维化.
主要成果:
- 在13.5%的参与者中,SCA存在.
- 在调整人口统计和生活方式后,MASLD和MetALD与SCA显著相关 (aOR分别为1.26和1.43).
- 随着对代谢因素的进一步调整,相关性减弱,但随着肝硬化和纤维化严重程度的增加,风险增加.
结论:
- MASLD和MetALD与增加SCA风险有关,特别是在肝硬化和纤维化同时存在的情况下.
- 代谢负担和肝病的严重程度似乎共同影响SCA的发展.
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