长期暴露于皮醇会通过人类干细胞衍生的大脑器官中的Notch1信号来损害神经发育
Hyunsu Kang1,2, Jae-Hyeok Lee2,3, Hana Cho4
1Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.
Scientific reports
|July 17, 2025
概括
长期使用哈洛佩里多尔会通过破坏Notch1信号来缩小大脑器官. 这种抗精神病副作用可以通过酸或酸减轻,这表明新的安全性评估.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 众所周知,抗精神病药物哈洛佩里多尔在长期使用时会减少大脑的大小.
- 皮醇诱导的大脑大小减小背后的机制尚未完全理解.
- 诺奇1信号传递对神经系统发育至关重要,调节干细胞活动.
研究的目的:
- 为了研究长期暴露于哈洛佩里多尔对人类大脑器官的影响.
- 探索Notch1信号传递在哈洛佩里多尔对神经发育的影响中的作用.
主要方法:
- 利用人类衍生的脑器官作为人脑发育的体外模型.
- 评估了慢性皮醇暴露对有机体大小,心室区域和Notch1信号传递的影响.
- 研究了酸的保护作用和酸 (Notch1激活剂) 的影响.
主要成果:
- 长期暴露于haloperidol减少了大脑器官体的大小,心室区域厚度和Notch1信号传输.
- 当与halooperidol同时使用时,氨酸治疗挽救了有机体大小和Notch1水平.
- 瓦尔酸部分恢复了有机体大小和心室层厚度.
结论:
- 长期使用哈洛佩里多尔会损害大脑器官中的神经发育,通过Notch1信号传递进行介导.
- 这些发现突出了与抗精神病药物使用相关的潜在神经发育毒性风险.
- 该研究为开发药物新型神经发育毒性评估提供了见解.
相关概念视频
03:14Notch Signaling Pathway
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