对急性胰腺炎及其与全身炎症相关的三种肠道微生物组诊断模型的开发:一项前性横截面研究
Yuanyuan Gou1, Long Yao2, Wenli Yang1
1Department of Gastroenterology, Chongqing University Jiangjin Hospital/Chongqing Jiangjin District Central Hospital, Chongqing, 402260, JiangJin, China.
Scientific reports
|July 17, 2025
概括
肠道微生物组的改变与急性胰腺炎 (AP) 有关. 像Veillonella parvula和Fusobacterium periodonticum这样的特定细菌与炎症相关,形成了AP的潜在诊断工具.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 翻译医学是一种翻译医学.
背景情况:
- 肠道微生物组失生症与急性胰腺炎 (AP) 的病原发生有关.
- 以前的研究集中在组成变化上,缺乏与临床炎症标志物的联系.
- 这项研究将特定的微生物特征与AP中的全身炎症联系起来.
研究的目的:
- 在AP中确定与系统性炎症相关的肠道微生物组生物标志物.
- 根据微生物签名开发AP的诊断模型.
- 探索微生物组分析在AP管理中的翻译应用.
主要方法:
- 从34名AP患者和20名健康对照组 (HC) 收集了便样本.
- 使用高通量16S rRNA测序进行分类分析.
- 采用随机森林和斯皮尔曼相关性分析来识别生物标志物并评估与炎症指标 (WBC,prokalcitonin) 的关联.
主要成果:
- AP患者的肠道微生物群多样性减少 (香农指数).
- 丰富了Fusobacterium periodonticum,Fusobacterium mortiferum和Veillonella parvula;在AP中观察到的Bacteroides plebeius和Faecalibacterium prausnitzii的枯竭.
- 一个三个物种的模型 (Veillonella parvula,Bacteroides plebeius,Fusobacterium periodonticum) 实现了高的诊断准确性 (AUC 0.94).
- 百叶菌 (Veillonella parvula) 和Fusobacterium periodonticum与白血球和前素水平呈正相关性.
结论:
- 证实了AP的组成和功能性肠道微生物组变化.
- 特定的微生物种类与AP炎症生物标志物密切相关.
- 经过验证的三种模型显示了作为AP的非侵入性诊断工具的潜力.
相关概念视频
Acute Pancreatitis I: Introduction
494
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
494
Acute Pancreatitis II: Clinical Manifestations and Management
180
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
180
Chronic Pancreatitis I: Introduction
166
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
166
Chronic Pancreatitis II: Collaborative Care
130
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
130
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
426
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
426


