非高密度脂蛋白与高密度脂蛋白胆固醇比率和骨矿物质密度之间的关联
Ying Zhou1, Ning Su1, Huimin Dai2
1Pharmacy Department, Xichang Municiple People's Hospital, Xichang, 615000, Sichuan, China.
Scientific reports
|July 17, 2025
概括
新的脂质指数,NHHR (非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率),与骨矿物质密度 (BMD) 相反相关. 这种U形关系表明,NHHR可能有助于早期诊断骨质疏松症,特别是在年轻人和女性中.
科学领域:
- 脂质代谢 脂质代谢是什么
- 骨健康 骨健康 骨健康
- 心脏代谢风险 心脏代谢风险
背景情况:
- 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率 (NHHR) 是一个新兴的复合脂质指数.
- 关于NHHR与骨矿物质密度 (BMD) 之间的关联存在有限的研究.
研究的目的:
- 在一个基于人口的大样本中调查NHHR和BMD之间的相关性.
- 探索潜在的非线性关系,并确定这种关联的值.
主要方法:
- 从2011-2018年NHANES数据集中对3,138名参与者的横截面分析.
- 利用加权多重线性回归,值效应分析,并拟合光滑曲线建模.
- 检查了NHHR四分位数,并根据年龄和性别进行了子组分析.
主要成果:
- NHHR与BMD有负相关性,表明骨密度较低,NHHR较高.
- 观察到一个显著的非线性,U形关系,在NHHR = 1.301.30 的拐点.
- 在20岁以下的参与者和女性中,NHHR和BMD之间的反向关联更为明显.
结论:
- NHHR可以作为BMD的独立生物标志物,特别是在青少年和妇女中.
- 这些发现突出了潜在的脂质-骨代谢交叉对话以及NHHR在早期骨质疏松症检测中的实用性.
- NHHR与BMD的U形协会为有针对性的干预和治疗策略提供了洞察力.
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