随着时间的推移,多环芳暴露的变化模式在中欧人口中发生了变化
Soňa Smetanová1, Akrem Jbebli1, Jiří Kohoutek1
1RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
Journal of exposure science & environmental epidemiology
|July 17, 2025
概括
多环芳化合物 (PAH) 代谢物水平在2011年至2020年间在捷克人口中显著下降,这是由于立法变化. 生物监测证实了公共卫生措施在减少PAH暴露方面的有效性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 监测化学物质暴露的时间趋势对于评估公共卫生干预措施至关重要.
- 捷克共和国在采样期间之间实施了包括吸烟限制和空气质量法在内的立法措施.
研究的目的:
- 调查捷克人口中多环芳 (PAH) 代谢物水平的时间趋势.
- 评估立法措施对PAH代谢物度的影响.
- 确定捷克人口中PAH代谢物的新参考值.
主要方法:
- 从母亲和儿童 (2011-2012) 和儿童,青少年和年轻人 (2019-2020) 收集了尿液样本.
- 量化了十个氧化PAH (OH-PAH) 的代谢物.
- 使用多变量统计分析,包括线性回归和ANOVA来评估差异并确定暴露决定因素.
主要成果:
- 在2011-2020年期间观察到OH-PAH代谢物中位数度的显著下降 (例如,1-OH-NAP的30-35%,1-OH-PHE的85%).
- 虽然一些代谢物在非吸烟成年人和儿童中增加,但总体趋势表明减少,特别是在吸烟者中.
- 饮食因素,季节,地区和方法都影响了OH-PAH水平,2011年吸烟是主要原因,但在2019年却没有.
结论:
- 该研究表明,捷克人口的PAH代谢物水平有所降低,这可能是由于立法干预.
- 随着时间的推移,生物监测对于评估公共卫生政策和告知未来措施至关重要.
- 确定了OH-PAHs的新参考值,有助于公共卫生决策.
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