在肥胖中超越脂肪:经常被忽视的肌肉质量的重要性
Refaat Hegazi1,2, Bruno Halpern3
1Department of Medical Affairs and Research, Abbott Nutrition, Columbus, OH, USA. refaat.hegazi@abbott.com.
Reviews in endocrine & metabolic disorders
|July 17, 2025
概括
肥胖的定义是不精确的,经常忽视肌肉质量. 新的肥胖药物可能会影响肌肉,强调需要将肌肉健康整合到肥胖护理中,以获得更好的结果.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 肥胖医学 肥胖医学
背景情况:
- 传统的肥胖定义缺乏准确性,并且无法解释个人身体组成的变化.
- 身体质量指数 (BMI) 是一个有缺陷的指标,因为它不能区分脂肪和瘦肉.
- 肥胖的健康风险与脂肪积累和缺乏无脂肪质量,特别是肌肉的缺陷有关.
研究的目的:
- 解决在临床肥胖管理中对肌肉健康的低估问题.
- 探索新的肥胖药物疗法,如GLP-1受体激动剂,在减肥期间对肌肉质量的影响.
- 倡导在肥胖护理中对身体成分变化的更全面的理解.
主要方法:
- 本特别号综合了关于将肌肉健康纳入肥胖管理的各种观点.
- 它回顾了有关人体组成和健康风险的现有证据.
- 它讨论了药物治疗对肌肉质量的影响.
主要成果:
- 新出现的证据表明,健康风险受到无脂肪质量的影响,而不仅仅是脂肪积累.
- 有关新型肥胖药物对肌肉质量的影响存在担忧.
- 对身体成分的全面了解对于有效的肥胖治疗至关重要.
结论:
- 目前的肥胖定义和诊断工具需要改进.
- 肌肉健康是肥胖管理的关键,但经常被忽视的组成部分.
- 整合肌肉健康方面的考虑对于优化肥胖个体的长期健康结果至关重要,特别是随着药物治疗的进步.
相关概念视频
Obesity
621
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
621
Exercise and Muscle Performance
1.6K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.6K
Hypodermis
5.4K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
5.4K
Overview of Protein Metabolism
1.9K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.9K
Overview of Lipid Metabolism
2.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.5K
Overview of Skeletal Muscle
12.4K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
12.4K


