早期发育里程碑与滴答和精神病理性并发症相关:一项EMTICS研究
Tamar Steinberg1,2, Dana Feldman-Sadeh1,2, Alan Apter1,2
1Department of Child and Adolescent Psychiatry, Schneider Children's Medical Center of Israel, 4920235, Petach Tikva, Israel.
European child & adolescent psychiatry
|July 17, 2025
概括
慢性滴答障碍 (CTD) 儿童的早期发育里程碑延迟与注意力缺陷/多动症障碍 (ADHD),自闭症谱系障碍 (ASD) 和其他并发症有关. 这凸显了对有风险儿童的早期检测的必要性.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科神经学 儿科神经学
- 儿童精神病学 儿童精神病学
背景情况:
- 慢性动障碍 (CTD),包括图雷特综合征 (TS),经常与精神病理相关疾病同时发生.
- 像注意力缺陷/多动症 (ADHD) 和自闭症谱系障碍 (ASD) 这样的疾病与发育迟缓有关.
- 早期发育里程碑,的严重程度和CTD的并发症之间的关系仍未得到充分研究.
研究的目的:
- 调查早期发育里程碑和CTD儿童的精神病理性并发症之间的关联.
- 探索儿科CTD患者发育里程碑,滴滴严重程度和功能障碍之间的联系.
主要方法:
- 在383名患有CTD的儿童 (3-16岁) 中,对早期发育里程碑的回顾性评估 (坐着,走路,第一句话,句子完成和禁欲).
- 使用经过验证的仪器评估的严重程度,与相关的功能障碍,强迫症 (OCD),多动症 (ADHD),反对性挑性障碍 (ODD) 和疑似ASD.
- 统计分析包括皮尔森相关性和后勤回归来确定关联.
主要成果:
- 在运动的严重程度/障碍和行走能力 (r=0.11),以及语音和第一句话 (r=0.12) 之间发现了小但显著的相关性.
- 延迟第一句话与ADHD (OR1.04-1.22) 显著相关,ODD (OR1.05-1.21) 和疑似ASD (OR1-1.13) 显著相关.
- 延迟步行获得与强迫症相关 (OR 1.01-1.27).
结论:
- 早期发育里程碑与CTD儿童的晚期精神病理性并发症有关.
- 这些发现强调了区分单独的滴答和伴随性疾病的儿童的重要性.
- 需要改善CTD和并发症风险儿童的早期检测策略.
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