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Updated: Sep 15, 2025

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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在人类卫星重复时,需要HELLS来维持适当的DNA修饰

Philine Guckelberger1,2, Leah Haut1,2, Rosaria Tornisiello1,3

  • 1Max Planck Institute for Molecular Genetics, Berlin, Germany.

Genome biology
|July 17, 2025
PubMed
概括

螺旋酶,淋巴体特异性 (HELLS) 蛋白对于维护DNA甲基化至关重要,特别是在重复性DNA区域. 它的破坏导致全球DNA甲基化损失,与DNA甲基转移酶 (DNMTs) 不同.

关键词:
中介质是中介质的组成部分.染色体重塑 染色体重塑 的方法通过DNA甲基化.地狱是一个地狱.卫星重复重复的时间在T2T上,T2T是T2T.

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