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Allergic Reactions02:06

Allergic Reactions

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Overview
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
981
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

469
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Updated: Sep 15, 2025

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

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微塑料吸入对过敏和非过敏鼻炎的影响

Yesim Itmec1, Aysegul Tuna2, Ayse Fusun Kalpaklioglu1

  • 1Department of Allergy and Immunology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey.

American journal of rhinology & allergy
|July 18, 2025
PubMed
概括
此摘要是机器生成的。

与健康对照人相比,过敏性鼻炎 (AR) 和非过敏性鼻炎 (NAR) 患者的鼻液中发现的微塑料度更高. 这表明微塑料可能会导致鼻炎患者的上呼吸道炎症.

关键词:
过敏性疾病是一种过敏性疾病.过敏性鼻炎 过敏性鼻炎表面上皮质屏障的一个障碍.微塑料微塑料的使用鼻洗 鼻洗 鼻子洗没有过敏的鼻炎.

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科学领域:

  • 环境健康 环境健康
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科
  • 毒理学 毒理学 毒理学

背景情况:

  • 微塑料是无处不在的环境污染物,具有已知的不良健康影响.
  • 微塑料对常见的炎症性鼻腔疾病 - - 鼻炎的具体影响仍未得到充分研究.
  • 吸入空气中的微塑料可以对呼吸道细胞产生有毒作用.

研究的目的:

  • 调查鼻洗液 (NLF) 中微塑料的存在和密度.
  • 将过敏性鼻炎 (AR) 和非过敏性鼻炎 (NAR) 患者的微塑料含量与对照组进行比较.
  • 探索微塑料密度与鼻炎症状 (如打喷) 之间的关联.

主要方法:

  • 鼻洗液 (NLF) 样本从90名参与者 (30名AR,30名NAR,30名对照) 中收集.
  • 在样本过后,使用立体显微镜进行了微塑料量化.
  • 对所有参与者记录了人口统计数据,过敏状况和症状得分.

主要成果:

  • 在所有鼻炎患者的NLF中观察到显著更高的微塑料密度 (3.10颗粒/毫升) 与对照组 (1.18颗粒/毫升) 相比 (P < .001).
  • 在AR和NAR组之间没有发现微塑料密度的显著差异.
  • 年轻年龄组的微塑料密度更高,与打喷的可能性增加相关 (OR = 2.20,P = .04).

结论:

  • 鼻水中的微塑料含量升高与鼻炎有关,不论过敏状态如何.
  • 即使在对照组中也检测到可量化的微塑料度,这表明暴露范围广泛.
  • 这些发现支持了微塑料导致上呼吸道炎症的假设.