西班牙针对痴呆症患者的抗精神病药物处方趋势
Antonio Sánchez-Soblechero1,2, Miguel Gil3, José Manuel Rojo4
1Neurology Department, University Hospital Gregorio Marañón, Madrid, Spain.
Journal of Alzheimer's disease : JAD
|July 18, 2025
概括
尽管有监管警告,西班牙对痴呆症患者 (PwD) 的抗精神病药物处方从2002年到2018年翻了一番. quetiapine的使用显著增加,突出需要更好的干预措施和非药物方法.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗精神病药物通常被处方给患有痴呆症 (PwD) 的个人.
- 人们对抗精神病药物使用在PWD中的风险益处平衡存在担忧.
- 2004年和2008年,有关抗精神病药物的使用,发布了监管警告.
研究的目的:
- 分析西班牙PWD抗精神病药物处方的趋势.
- 评估监管警告对抗精神病药物处方模式的影响.
- 将西班牙的处方趋势与其他国家的处方趋势进行比较.
主要方法:
- 这是一项使用2002年至2018年初级保健中西班牙药物流行病学研究数据库 (BIFAP) 进行的纵向回顾性研究.
- 包括患有发病性痴呆症的患者,不包括患有重大精神疾病或先前使用过抗精神病药物的患者.
- 对抗精神病药物处方数据的分析,包括按性别分层的年度流行率计算.
主要成果:
- 在PWD中,抗精神病药物处方的流行率从2002年的12.6%翻了一番,到2018年的23.8%.
- 从2004年至2007年间,观察到暂时的下降,随后稳步增加,主要是由非典型的抗精神病药物 (如奎平) 推动的.
- 奎胺使用率从0.2%增加到16.4%,男性使用率更高;西班牙的患病率是英国的两倍.
结论:
- 加强监管警告可以帮助西班牙和全球合理化抗精神病药物的使用,理想情况下可以整合到国家痴呆症战略中.
- 迫切需要在痴呆症护理中促进神经精神病症状的非药物干预.
- 监管机构应紧急解决该群体中高水平使用奎氨酸的问题.
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