绝经期激素治疗对女性流感并发症的影响:一项系统评估研究

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Yu-Hsiang Shih^1,2, Chiao-Yu Yang^2,3, Chia-Chi Lung^2,4,5

¹Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan.

Annals of medicine

|July 18, 2025

概括

更年期激素治疗 (MHT) 在没有慢性疾病的46-60岁女性中显著减少了肺部并发症. 在那些有先前存在的健康问题或接受抗病毒治疗的人群中,MHT没有显示出保护作用.

科学领域:

妇女健康妇女健康
传染病流行病学传染病流行病学
药理干预药理干预

背景情况:

有限的研究存在于更年期激素治疗 (MHT) 对流感结果的影响.
了解MHT对呼吸道感染的影响对于绝经后妇女的健康至关重要.
流感带来了严重的呼吸系统风险,特别是在弱势群体中.

研究的目的:

调查MHT使用与流感相关的呼吸道发病率之间的关联.
评估MHT对流感感染后肺部并发症的保护作用.
分析MHT在特定小组的疗效,包括那些患有慢性疾病的人.

主要方法:

使用TrinetX美国协作网络数据 (2010-2019) 的回顾性队列研究.
包括46-60岁的被诊断患有流感的个人,在前一年未接种疫苗.
倾向性得分匹配 (PSM) 以平衡基于人口统计和并发症的队列.

主要成果:

在46-60岁的女性中,使用MHT与肺部并发症 (肺炎,呼吸衰竭) 的减少约40%有关.
在患有慢性疾病 (糖尿病,高血压,心脏/肺部疾病) 的患者中,没有观察到MHT的显著保护作用.
在接受流感抗病毒治疗的患者中,MHT并没有减少呼吸道并发症.

结论:

更年期荷尔蒙疗法 (MHT) 在患有流感的健康绝经后妇女 (46-60) 中显示出对肺部并发症的显著保护作用.
在患有先前存在的慢性疾病的妇女中,MHT对流感结果的益处可能是有限的.
需要进一步的研究来阐明MHT在不同患者群体的传染性呼吸道疾病管理中的作用.

关键词:

绝经期的荷尔蒙治疗.这是一个复杂的并发症.流感流感流感流感流感

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