在皮肤瘤学中对药物安全性和药物坚持的影响:AMBORA治疗方案用于口服抗瘤疗法
Lisa Cuba1,2,3,4,5, Frank Dörje1,3,4,6, Rafaela Kramer3,4,7
1Pharmacy Department, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
概括
安博拉护理计划通过解决大多数错误并确保高患者坚持治疗,提高了皮肤口服抗瘤疗法 (OAT) 的药物安全性. 这突显了临床药剂师在皮肤瘤学中的重要性.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 皮肤口服抗瘤疗法 (OAT) 容易发生药物相互作用和复杂的治疗方案.
- 之前的AMBORA试验改善了OAT的药物安全性,但排除了皮肤瘤患者.
- 安博拉护理计划适应了皮肤瘤学中的临床常规.
研究的目的:
- 分析接受皮肤学OAT的患者的药物错误和药物坚持.
- 评估AMBORA护理计划在皮肤瘤学中的有效性.
主要方法:
- 药物错误使用PCNE V9.1.1.进行分类.
- 通过药物事件监测系统 (MEMS按) 和MARS-D问卷来测量守.
- 主要结局包括12周内解决的涉及OAT的错误和剂量坚持 (DA).
主要成果:
- 92名患者 (81.5%黑色素瘤) 经历了1.6个药物错误/患者,其中61.6%涉及OAT.
- 89.2%的OAT相关的药物错误得到了解决.
- 在48名可评估患者中,中位数剂量坚持率 (DA) 为95.0%;每日一次OAT疗程的DA更高.
结论:
- 跨专业的AMBORA护理计划有效地解决了药物错误,并促进了皮肤瘤学的高度遵守.
- 基于证据的药物管理和临床药理学家/药剂师的患者咨询提高了皮肤瘤学中的药物安全性.
- 安博拉计划在优化皮肤瘤学环境中的OAT使用方面具有显著价值.
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