干白素-6,C反应蛋白,以及中风后的血管复发,有或没有动脉样硬化
John J McCabe1,2,3, Katie Harris4, Cathal Walsh1,5
1Health Research Board (HRB) Stroke Clinical Trials Network Ireland (SCTNI) (J.J.M., C.W., S.G., P.J.K.).
Stroke
|July 18, 2025
概括
炎症标志物,如干白素-6 (IL-6) 和高灵敏性C反应蛋白 (hsCRP) 预测中风复发,即使在没有动脉样硬化的患者中也是如此. 升高的水平表明风险增加,支持对这些人的抗炎疗法试验.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症在中风后复发中的作用,特别是在没有动脉样硬化症的患者中,仍然不清楚.
- 动脉样硬化状态可能会影响中风后炎症标志物和不良心血管事件之间的关联.
研究的目的:
- 评估动脉样硬化状态如何影响炎症标志物 (IL-6,hsCRP) 与中风后主要心血管不良事件 (MACE) 之间的联系.
- 确定炎症标志物是否预测动脉样硬化或不动脉样硬化患者的复发性中风或MACE.
主要方法:
- 11个潜在队列 (1995-2017年) 的个人参与者数据元分析,包括患有缺血性中风/暂时缺血性发作的患者.
- 在事件发生后测量介白素-6 (IL-6) 和高灵敏性C反应蛋白 (hsCRP).
- 对心血管风险因素进行调整的分层考克斯回归分析,根据动脉样硬化存在,检查与复发性中风/MACE的关联.
主要成果:
- 在动脉样硬化患者中,IL-6与MACE和复发性中风独立相关.
- 与最低四分位数相比,较高的IL-6水平 (上四分位数) 将MACE和中风的风险增加了一倍.
- 在患有动脉样硬化和没有动脉样硬化的患者中,IL-6和hsCRP与MACE相关;在非动脉样硬化患者中,hsCRP也与MACE相关.
结论:
- 干白素-6 (IL-6) 和高灵敏性C反应蛋白 (hsCRP) 预测中风后的复发独立于动脉样硬化.
- 结果支持在抗炎疗法试验中包括患有IL-6或hsCRP升高的患者,即使没有先前的动脉样硬化事件,在中风后.
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