相关实验视频
Updated: Sep 15, 2025
11:18
Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
7.6K
哺乳期患有CKD的妇女使用药物的安全性
Paula Parnizari1, Michelle A Hladunewich2,3, Jonathan Zipursky2,4
1Centro de Nefrología, Hospital de Clinicas "Manuel Quintela", Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Kidney international reports
|July 18, 2025
概括
哺乳是安全的,与某些慢性病 (CKD) 药物,如伊纳拉普利和卡波普利. 对于许多其他CKD药物的数据有限,因此在哺乳期需要谨慎使用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
- 哺乳期医学 哺乳期医学
背景情况:
- 哺乳提供了显著的健康益处.
- 缺乏关于哺乳期药物安全性的证据,阻碍了母乳养和慢性脏病 (CKD) 治疗.
- 需要对CKD药物的母乳养安全进行系统审查.
研究的目的:
- 系统地审查常用于慢性脏病 (CKD) 的药物的母乳养安全证据.
- 为临床医生和患者提供基于证据的指导,关于在CKD中哺乳期间使用药物的指导.
- 为了确定CKD患者在母乳养期间药物安全性的知识差距.
主要方法:
- 在PUBMED,REPROTOX和LACTMED进行了文献搜索.
- 审查了81项观察研究和病例报告.
- 关于哺乳期药物安全性的综合发现.
主要成果:
- 伊那拉普利和卡普托普利 (胺-血管激素系统抑制剂) 是安全的母乳养.
- 奎那普里尔,贝纳泽普里尔,坎德沙坦和瓦尔沙坦可能是可以接受的.
- 对于SGLT2抑制剂,GLP1RAs,finerenone,sparsentan,mycophenolate和较新的补充抑制剂,数据有限或相互矛盾;建议谨慎使用.
结论:
- 有限的人类哺乳期数据挑战了基于证据的CKD药物使用建议.
- 新兴的药物指标可以帮助对母乳养人口的药物安全性进行评估.
- 进一步的研究至关重要,以确保为患有CKD的母乳养母亲提供安全的药物实践.
相关概念视频
01:11Renal Failure: Dose Adjustments
161
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
161
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
58
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
58
01:18Chronic Kidney Disease IV: Nursing Management
59
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
59
01:28Chronic Kidney Disease III: Interprofessional Care
80
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
80
01:21Factors Affecting Drug Response: Overview
2.4K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.4K
01:17Factors Affecting Renal Clearance: Renal Impairment
162
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
162