免疫检查点抑制剂对消化系统相关不良影响的内镜洞察:叙述性综述
Grigorios Petrousis1,2, Sylwester Szczegielniak3, Haider Sabhan4,5
1Centre for Digestive Health, Department of Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm 17164, Sweden.
免疫检查点抑制剂 (ICI) 改善癌症存活率,但可能导致胃肠道副作用. 本综述详细介绍了这些与免疫相关的不良事件 (irAEs),重点关注内镜检测结果和管理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI) 为癌症患者提供了显著的生存益处.
- 常见的ICI向被编程细胞死亡-1 (PD-1),被编程细胞死亡-1 (PD-L1) 和细胞毒性T淋巴细胞抗原4 (CTLA-4) 受体.
- ICI治疗与免疫相关的不良事件 (irAEs) 相关,特别是影响胃肠道.
研究的目的:
- 为提供与ICI相关的初级胃肠道IRAE的概述.
- 为了突出胃肠道IRAE的内镜表现.
- 分析病原,诊断,组织学和胃肠道IRAE的治疗.
主要方法:
- 在PubMed,科学网,Embase和Cochrane图书馆进行了全面的文献搜索.
- 专注于详细介绍胃肠道免疫相关不良事件的研究.
- 包括有关内镜发现,机制,诊断,组织学和治疗学的数据.
主要成果:
- 胃肠道IRAE是影响患者生活质量的重要问题.
- 内镜检测结果为IRE提供了关键的诊断信息.
- 了解病原遗传机制有助于制定有效的管理策略.
结论:
- 胃肠道IRAE在ICI治疗中是一个关键的临床挑战.
- 内镜评估对于诊断和管理这些事件至关重要.
- 对病原和向治疗的进一步研究是有必要的,以获得最佳的患者护理.
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