内分细胞检测在实时评估性结肠炎的组织学和内分镜活动
Thanaboon Chaemsupaphan1,2, Mohammad Shir Ali1, Caroline Fung3
1Department of Gastroenterology and Liver Services, Concord Repatriation General Hospital, Sydney 2139, New South Wales, Australia.
实时内分细胞镜准确评估性结肠炎 (UC) 活动,与组织学发现相对应. 与ECSS相比,ELECT得分在识别组织学缓解方面表现出更高的准确性.
科学领域:
- 胃肠病学 胃肠病学
- 内镜成像系统的成像
- 炎症性肠道疾病研究研究
背景情况:
- 内分泌镜检查提供实时,超高放大肠道粘膜.
- 评估内镜和组织学缓解对于治疗性结肠炎至关重要.
- 内细胞镜检查可以通过使在体内显微镜评估,潜在地简化工作流程.
研究的目的:
- 评估实时内分细胞检查在评估UC的内镜和组织学疾病活动中的实用性.
- 验证内细胞镜评分系统,包括ERLangen Endocytoscopy in ColiTis (ELECT) 评分和内细胞镜评分 (ECSS).
主要方法:
- 患有UC的患者接受了结肠镜检查和内细胞镜检查.
- 细胞内学特征与梅奥内学评分 (MES) 和南希组织学指数相关.
- 卡帕统计和斯皮尔曼相关系数被用来评估协议和验证.
主要成果:
- 内细胞镜检查显示与使用ECSS和ELECT分数的MES和Nancy组织学指数有显著的相关性.
- 在确定组织学缓解 (100%的灵敏度,85%的特异性) 中,ELECT得分显示出卓越的诊断准确性.
- 没有报告任何严重的不良事件,只有暂时的尿路变色.
结论:
- 细胞内镜能够准确,安全和耐受性良好的实时评估UC的内镜和组织学活动.
- 与ECSS相比,ELECT得分与组织学发现具有更好的一致性.
- 这种模式有可能提高管理UC的效率.
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