酸乙烯乙醇和乙基葡萄化物用于将酒精消费归类为与酒精有关的肝硬化
Benedict T K Vanlerberghe1,2,3,4, Catalina Dumitrascu5, Nele Van den Eede6
1Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
JHEP reports : innovation in hepatology
|July 18, 2025
概括
氨酸乙醇 (PEth) 和乙基葡萄糖胺 (EtG) 生物标志物在肝硬化患者中准确地检测出酒精使用,PEth和指甲EtG (nEtG) 在不同的检测窗口中显示出希望.
科学领域:
- 临床毒理学中的生物标志物分析.
- 肝病学和肝病研究研究.
- 酒精使用障碍诊断诊断使用障碍诊断
背景情况:
- 氨酸乙醇 (PEth) 是一种酒精使用生物标志物,有可能弥合尿道乙烯基葡萄糖化物 (uEtG) 和头皮头发乙烯基葡萄糖化物 (hEtG) 之间的检测差距.
- 对于肝病患者的Peth存在有限的验证,现有的研究往往只关注任何酒精使用.
- 分类酒精消费水平对于管理肝病患者至关重要.
研究的目的:
- 评估全血PEth,uEtG,hEtG和指甲乙基葡萄糖化物 (nEtG) 的诊断准确性和最佳检测窗口.
- 评估这些生物标志物,以检测与酒精有关的肝硬化患者的不同程度的酒精使用 (任何,增加,过度) 的情况.
主要方法:
- 116名酒精相关肝硬化患者使用酒精时间线追踪对3个月的酒精使用进行了评估.
- 评估的检测窗口:1-7天 (uEtG),1-5周 (PEth) 和3个月 (hEtG和nEtG).
- 对任何,增加和过度饮酒类别的诊断准确性被确定.
主要成果:
- uEtG,PEth和hEtG显示出任何酒精使用的高诊断准确度,最佳检测窗口分别为3天,3周和3个月.
- 这三种生物标志物都显示出高负预测值 (>92%) 以排除增加和过度饮酒.
- 在3个月的时间内,nEtG显示出有希望的诊断准确度,可以检测任何酒精使用情况,这表明它可能是hEtG.的替代品.
结论:
- PEth和EtG生物标志物为识别任何酒精使用和排除酒精相关肝硬化患者增加使用提供了卓越和互补的准确性.
- 在长期酒精使用监测中,nEtG是hEtG的潜在替代品,尽管建议进一步验证.
- 这些经过验证的生物标志物有助于临床护理和研究与酒精有关的肝脏和脂肪性肝脏疾病.
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