由于对甲状腺激素替代剂的过敏反应延迟而导致的不对称外周胀的罕见病例
Quynh Nguyen1, Hoang V K Dinh2, Vien Phan3
1Department of Internal Medicine, Logan Regional Medical Center, Logan, West Virginia.
AACE endocrinology and diabetes
|July 18, 2025
概括
对levothyroxine的过敏反应很少发生,但可能由于辅助剂而发生. 一种延迟的外视周胀病例通过切换到含有更少不活性成分的配方成功治疗.
科学领域:
- 内分泌学 在内分泌学.
- 过敏学 过敏学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对药物的过敏反应由于个体变异性而带来诊断挑战.
- 对levothyroxine过敏不常见,但配方中的助剂可以引发过敏反应.
- 延迟过敏反应需要在药物管理中仔细考虑.
研究的目的:
- 报告一个异常情况下的延迟过敏反应对levothyroxine.
- 突出助剂在药物诱导过敏表现中的作用.
- 强调配方变化的实用性,以管理药物过敏.
主要方法:
- 一个77岁的妇女的病例报告经历了反复复发的不对称的外围耳周胀.
- 诊断过程涉及不同类型的levothyroxine配方的连续试验.
- 在药物停用后症状的消失和在药物重新引入后复发的临床观察.
主要成果:
- 患者在开始服用levothyroxine后1至2个月内出现了孤立的不对称的围耳胀.
- 这种反应在levothyroxine撤销后消失,并与品牌名Synthroid复发.
- 切换到含有更少无活性成分的Tirosint囊,成功地解决了过敏反应.
结论:
- 这种病例表明了对levothyroxine的罕见延迟过敏反应.
- 列沃西配方中的辅助物质可以引发过敏反应,即使在非典型的呈现中.
- 使用含有最小辅料的配方是一种可行的策略,用于管理疑似药物过敏并避免脱敏.
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